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Bosilkovska M, Walder B, Besson M, et al

An invited commentary on this study, also published in JAMA Ophthalmology, challenges the idea that the increased risk of NAION among semaglutide users resulted directly from the medication

Its unique profile (native gastric peptide, stable without carriers, effective at nanogram doses, modulating multiple interconnected neurotransmitter systems simultaneously, promoting actual neuronal repair rather than just symptomatic relief) distinguishes it from all existing psychiatric medications

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Community protocols avoid raising both compounds at once, stepping retatrutide up first before adding MOTS-c