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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

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In the present study, cysteine and spermidine contents increased significantly but no differences between treatment T4 and T3, suggesting regulatory mechanisms occurring in response to cysteine and spermidine and involving both transcriptional and post-translational levels (Fig

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