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dose titration: 10 and 15 g during weeks 1 and 2, respectively
Notably, fecal microbiota transplantation from individuals with MDD into microbiota-depleted rodents induces depressive-like behaviour, accompanied by elevated plasma KYN and increased KYN/TRP ratios [191]
Determination of the IC 50 values for these compounds in CHO K1 cells expressing human TRPV1 revealed that exendin 939 had the lowest IC 50 value for inhibiting CAP-induced TRPV1 activation
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