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(1993) The heparin target organthe endothelium

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In male rats exposed to electric foot shocks, levels of TRP, KYN, 3-HK, and KYNA shift dramatically across plasma and multiple brain regions, normalizing within 24 h suggesting a dynamic and time-sensitive response of KP metabolism to stress [69]

Indirect calorimetry demonstrates higher fatty-acid oxidation and resting energy expenditure after dosing, consistent with an ERR-driven shift toward oxidative metabolism