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Drug absorption and interactions: Delayed gastric emptying can theoretically affect the absorption kinetics of orally administered medications, particularly those with narrow therapeutic windows or requiring rapid onset
This is just one piece of the puzzle
In clinical trials: Semaglutide: Approximately 7% discontinued due to adverse events Tirzepatide: Approximately 4-7% discontinued due to adverse events (dose dependent) Retatrutide: Approximately 6-10% discontinued due to adverse events (dose dependent) These rates are relatively close, suggesting that despite the differences in mechanism and side effect profiles, all three medications are tolerable for the vast majority of people who start them
Metformin is more affordable but less effective for weight loss
Combined, these effects can support healthy joints
