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While FDA-approved GLP-1 RAs have transformed the treatment landscape for obesity and diabetes through their effects on appetite, glycemic control, and weight reduction, glutathione may offer complementary benefits by addressing the oxidative stress component of metabolic dysfunction

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But when this is insufficient, patients options are limited

Our risk stratified UM option includes additional clinical rigor such as the submission of chart notes and step therapy prior to reauthorizing weight loss treatment with a GLP-1 drug

The trial also featured a "novel, patient-centric approach to clinical trial design." Placebo participants who regained 50% or more of their weight were eligible for rescue therapy with orforglipron