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These medications should be part of a comprehensive weight management program including dietary modification and increased physical activity, with treatment plans individualized based on patient response and tolerability
The identification of a distinct, non-IGF-1R MGF receptor remains an active research goal
In these trials, the medication was started at a very low dose, and the dosage was escalated gradually to maximize efficacy while minimizing early adverse effects, particularly gastrointestinal events that were consistent with Phase 2
Overall, SGLT2i as a class have shown renoprotection and reduced composite measures of adverse renal effects by 45% (HR: 0.55
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