Approximately 5090% of the body's total B12 stores reside in the liver, making hepatic function important for maintaining adequate B12 status over time
Carolyn Jasik, chief medical officer for Omada Health
If it holds up in larger, biopsy-confirmed studies, hepatic steatosis could become one of the areas where triple agonism has the strongest differentiated rationale though, as with everything about this molecule, that remains to be confirmed in the full program
Serotonin promotes mood, cognitive flexibility , and sociability (3-5) , and attenuates aggression and impulsivity (6)
Figure: Brain-to-plasma ratios at different time points following nasal administration of three doses of intranasal semaglutide (brain values represent one hemisphere)