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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

B12 is non-toxic at any dosage and does not have any negative side effects

For many research protocols, particularly those involving long-term observations or where ease of administration is a significant factor, an oral compound is often the first choice

The MIC nutrients are included for roles in methylation and hepatic lipid handling, while B12 (cobalamin) supports red-blood-cell formation and one-carbon metabolism

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