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Proteomics: Affects enzymes and structural proteins essential for extracellular matrix repair

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Furthermore, alterations in lipid peroxidation biomarkers (lipid ROS, GPX4, SLC7A11, ALOX5, and ASLC4) were noted in both the STZ-induced diabetic limb ischemia mouse model and human microvascular endothelial cells under diabetic limb ischemia conditions, indicating a potential role of ferroptosis in diabetic limb ischemia

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