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This action leads to closure of glucose-dependent ATP-sensitive K + channels which depolarizes the cell and thereby opens voltage dependent Ca 2+ channels allowing Ca 2+ influx which stimulates insulin secretion
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The most common AEs of GLP-1RAs are gastrointestinal complaints, such as nausea, vomiting, constipation, and diarrhea
Interestingly, this binding site is also shared by GLD-3, a protein that doesnt affect FBF target selection, but rather might change FBF regulatory outcome from translational repression to translational activation
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