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ACD occurs in response to environmental perturbations, i.e., any mechanical insult compromising the membrane integrity
doi:10.1186/s13018-025-05489-6 Dzidzishvili L, Berreta RS, Jackson GR, et al
However, unlike GPX7, which is a transmembrane protein that contains a C-terminal KEDL endoplasmic reticulum localization sequence and a highly conserved N-terminal transmembrane domain (TMD) (Yoboue et al., 2017)
It is sometimes prescribed off-label to manage generalized anxiety, especially when traditional anxiolytics are not suitable
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