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Observational data have suggested lower all-cause mortality with GLP-1 RA use compared with other glucose-lowering therapies in advanced CKD ( AKI occurred in four of the seven non-dialysis patients (57.1%)
While GLP-1 medications provide powerful support for weight management, the degree of weight loss depends heavily on adherence to a modest caloric deficit below total daily energy expenditure and on engaging in regular physical activity to increase caloric utilization, he explains
These effects are tied to changes in gut-derived hormones, which may further modulate insulin dynamics, satiety, and energy balance