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As is typical for trials of agents to treat type 2 diabetes, the mean reduction in A1C with Januvia appears to be related to the degree of A1C elevation at baseline

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A discussion of other agents, such as dipeptidyl peptidase-4 inhibitors, with less well-established CVD risk reduction profiles is beyond the scope of this review, and we refer the interested reader to prior reviews for an examination of other antidiabetic drug classes for CVD risk reduction in the high-risk adult with T2D (10,11)

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