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Furthermore, to address issues like dose standardisation and individual response variability, extensive, randomised clinical trials are required to validate the safety and effectiveness of flavonoids

However, some studies have shown that high dose-usage (greater than 2000 mg per day) does increase the risk of upper gastrointestinal complications.[25] Paracetamol is safe in pregnancy, and does not affect the closure of the fetal ductus arteriosus as NSAIDs can

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