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It was first identified in human plasma and has since become a major subject of interest in regenerative biology, tissue engineering, and extracellular matrix research

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doi:10.4088/JCP.09m05324gre Williams JL, Everett JM, D'Cunha NM, et al

The most important factor is consistency of timing and route day to day, since the mechanism works cumulatively rather than as an acute event to time around a meal

Better sleep is important for pain management and immune function, as sleep deprivation worsens inflammatory responses