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GLP-1s are not miracle drugs for two reasons But theres a key difference between GLP-1s and historic miracle drugs such as penicillin or the polio vaccine
403,404 Alterations in gut microbiota can increase intestinal permeability, leading to the translocation of endotoxins and the activation of immune responses that contribute to peripheral nerve damage
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Rybelsus led Novos portfolio with an 18% increase, while Ozempic and Victoza saw slower growth at 3.83% and 3.85% respectively
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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