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Most users notice visible improvements in skin tone and radiance after 46 weeks of consistent use

Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies

At the same time, the way in which people choose to imbibe the drug also is changing

One such option is GLP-1 therapy, which includes medications such as semaglutide ( Ozempic , Wegovy) and liraglutide (Saxenda, Victoza)

Buyers who use supplements as part of a broader, lifestyle-grounded approach - rather than as a standalone fix - tend to have more realistic expectations and more useful outcomes from any product in this category