Issue: September 2025 FORMULATION DEVELOPMENT - Innovative Drug Delivery Approaches for GLP-1 Agonists: Enhancing Medication Adherence & Treatment Outcomes INTRODUCTION Obesity is a major global health issue, affecting more than 890 million adults
Lets look at what people might expect if retatrutide is approved and how that would be different from the current GLP-1 medication options available today
A perspective published in PLOS Medicine by Chao, Gilden, and Wadden notes that GLP-1 and dual-agonist therapies have transformed obesity care, with efficacy that rivals some bariatric procedures in selected trials as demonstrated in major Phase 3 programs while the system-level challenges of capacity, monitoring, and access remain significant
The natural history of NAFLD spans decades, so longer-term studies are needed to confirm whether GLP-1 agonists can prevent progression to advanced fibrosis, cirrhosis, or hepatocellular carcinoma
Many patients report less nausea when injecting on an evening they plan to sleep, allowing their body to adapt during rest rather than while active