The peptide delivers controlled minimal copper amounts, prevents copper-mediated oxidative damage, has 40+ years of safe use history, and requires doses thousands of times higher than therapeutic range to cause toxicity
Consequently, this leads to a reduction in ROS production, MDA levels, and H 2 O 2 content, thereby maintain cellular membrane integrity
Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment
Interestingly, Kulak et al
The clinical question is what to do about it: dose adjustment, titration change, lifestyle review, or sometimes a switch to a different molecule