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As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]

Your GP's role is to ensure any intervention is in your best interests, balances potential benefits against risks, and aligns with current clinical guidelines

Reduced expression of collagen VI alpha 3 (COL6A3) confers resistance to inflammation-induced MCP1 expression in adipocytes

It shows up in wellness clinics but the clinical file behind it is thin

Pelvic floor dysfunction, which affects how the muscles involved in bowel movements work, can also play a role