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This biphasic response curve, where both microgram and nanogram doses work equally well, is unusual and mechanistically unclear
These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds
This highlights the precision and rapid distribution achieved through IV administration [7]
Nguyen TT, Ngo LQ , Promsudthi A, Surarit R
doi: 10.1016/j.anireprosci.2020.106330, 160
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