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The majority of drugs designed to target this problem were stimulants, an approach that had solid evidence to back up its efficacy: Stimulants activate reward mechanisms by interacting with amine transporter systems, decreasing the synaptic reuptake of dopamine and noradrenaline, and to a lesser extent serotonin so that neurotransmission is enhanced
It accomplishes this through enhanced insulin secretion, reduced glucagon release (paradoxically, since it only hits GLP-1 receptors), and improved beta-cell function
Research on GLP-1 receptor agonists and the gut microbiome reveals several consistent patterns
doi: 10.3389/fphar.2017.00362 109 WangZFanLNiYWuDMaAZhaoYet al
Im not overweight, but I am in my 40s and my metabolism is certainly beginning to slow down
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