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Those with a history of gastroparesis, GERD, inflammatory bowel disease, or previous gastrointestinal surgery may experience more pronounced symptoms and should have a lower threshold for seeking medical advice

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Dehydration and electrolyte imbalance represent one plausible explanation

For some people that means staying on treatment at a lower dose, for others it means coming off entirely

6 UK consensus guidance from the Association of Anaesthetists and the Royal College of Anaesthetists recommends pausing weekly GLP-1 medications, including Mounjaro, for 1 week before elective surgery requiring sedation or general anaesthesia