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Nevertheless, as some human MTCs may express GLP-1 receptors, these agents are not recommended for individuals with a personal or family history of MTC or multiple endocrine neoplasia type 2

11 Moreover, leptin receptor expression has previously been coupled to the appetite inhibition of GLP-1, 22 and recent studies in rodents have shown that GLP-1RAs can restore leptin responsiveness

doi: 10.1212/WNL.0000000000008785 44 JonklaasJ

"Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study." Diabetes, Obesity and Metabolism