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J Clin Invest 79: 616-619, 1987

Because Retatrutide remains an investigational GLP-3 triple hormone receptor agonist , the information below summarizes what researchers observed in clinical trials

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Lilly's first Phase 3 readout (TRIUMPH4) reported strong results in people with obesity/overweight and knee osteoarthritis, including: ~28.7% average weight loss at 68 weeks at the 12 mg dose (topline reporting), plus improvements in pain and function measures The important phrase there is "topline"

Effect of dipeptidyl peptidase-4 inhibitors on plasma adiponectin: a systematic review and meta-analysis of randomized controlled trials effect of dipeptidyl peptidase-4 inhibitors on plasma adiponectin: a systematic review and meta-analysis of randomized controlled trials 2 3