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NPS prevalence, severity, and timeline may differ depending on specific types of AD

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S-Methylglutathione, which is lacking the free thiol group present in glutathione, stimulates neither the nonenzymatic nor the GST-catalyzed isomerization, but inhibits the glutathione-independent GST catalysis (Pettersson and Mannervik, 2001)

Scaling of prospective inhaled clinical doses from an adult dose, based solely on relative body weight or body surface area does not account for the change in delivery efficiency of the formulation to paediatric populations compared to adults

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