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A 2020 study in Nutrients found that hydrolyzed collagen peptides stimulated GLP-1 secretion in human enteroendocrine cells

doi:10.3389/fphar.2022.935823

J Toxicol Environ Health

So if you take like 500 milligrams or 1,000 milligrams per day, it's plenty

These results, combined with orforgliprons once-daily oral dosing and broad scalability, reinforce its potential as a foundational treatment for type 2 diabetes. Eli Lilly also recently presented detailed results from the ATTAIN-1 trial, which investigated orforglipron in adults with obesity or overweight without diabetes, at the European Association for the Study of Diabetes (EASD) Annual Meeting 2025