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The latest SUSTAIN trial was published in 2022 that showed semaglutide once a week led to greater HBA1C reduction as compared to insulin aspart thrice per day

DPP-4i have been associated with a reduction in atherosclerosis and inflammation in several studies utilizing animal models [78,79,80]

doi:10.1371/journal.pone.0040156 11

This list doesnt include all possible side effects

In turn, this may contribute to the development of depression by increasing oxidative stress, DNA damage, and cell death in the body ( A 2020 study with 132 children and teens, 89 with and 43 without depression, found that the participants with depression had lower B12 levels and higher levels of homocysteine compared with those without depression ( In addition to depressive symptoms, low or deficient B12 levels may lead to other mental conditions, including psychosis and mood disorders ( Because a deficiency in B12 negatively impacts the central nervous system, people with low or deficient B12 levels may feel foggy-headed and have difficulty concentrating and completing tasks ( Fortunately, studies show that mental impairment related to low B12 levels can improve with B12 treatment