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This heterogeneity constrains quantitative synthesis and complicates direct comparisons across agents or CKD stages, reinforcing the value of an evidence-mapping approach rather than effect-size pooling
The most significant byproduct of this anaerobic shift is the rapid accumulation of lactic acid, leading to prolonged intramuscular acidosis
Similarly, cognitive changes accompanied by severe dehydration symptoms (decreased urination, dark urine, dizziness, rapid heartbeat) warrant prompt assessment, as significant fluid and electrolyte disturbances can have serious consequences
Also, if you don't get enough sleep, you can't exercise properly, you're not going to be organized, and youll feel bad
The p-values reported in all figures come from the hypothesis testing for the Kaplan-Meier survival curves and were conducted using the log-rank test
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