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Nevertheless, the combinatorial treatment with tamoxifen and antioxidants could promote anti-cancer efficacy of tamoxifen as was demonstrated in the model of DMBA-induced mammary carcinogenesis in SpragueDawley rats in which an administration of tamoxifen in combination with riboflavin, niacin, and coenzyme Q10 restored lipid peroxide level and the activity of anti-oxidants accompanied by enhanced antitumor activity [110]

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Traditional claims data alone, however, cannot answer many of these critical questions