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Acar T, Kamer E, Acar N, Atahan K, Bag H, Haciyanli M, Akgul O
Known inhibitors of TGRs/TrxRs, which include metal complexes and compounds containing Michael acceptors or oxadiazole oxides 19,23,24 , usually react with Sec and Cys residues and other biogenic nucleophiles irreversibly
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Furthermore, comorbidities such as hypertension (56.6%), obesity (41.7%), and diabetes (33.8%) are frequently linked to OxS and chronic inflammation in hospitalized COVID-19 patients 596
Notably, all COP1 WD40 domains in each layer face upward, while their coiled-coil domains are positioned downward, stacking onto the WD40 domains of the COP1 molecules in the subsequent layer
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