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It has been shown that the stimulatory effect of GLP-1 on insulin secretion is, to some extent, dependent on PKC, as evidenced by the ability of the PKC activator phorbol 12-myristate 13-acetate to mimic the effects of GLP-1 on electrical activity

They also slow down the emptying of the stomach, so patients feel satisfied longer after eating smaller meals

But none of this happens fast

doi: 10.1042/bj20082222 15 YangWYuTHuangXBilottaAJXuLLuYet al

19,20 With aging, mitochondrial function declines, leading to decreased energy metabolism, increased ROS production, and the accumulation of mtDNA mutations, alongside the deterioration of other mitochondrial functions