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According to recently published clinical research by Galderma in January 2025, patients using GLP-1 medications frequently report significant facial alterations: Loss of facial volume creating shadowing and hollowness Increased skin laxity and sagging Changes in facial structure and balance Skin appearing less radiant and drier An overall aged appearance beyond their chronological age Dr

Abstract Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two incretins that bind to their respective receptors and activate the downstream signaling in various tissues and organs

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Arillotta et al., highlighted a younger cohort, with a mean age of 38 years, but similarly found females to be the majority at 58% [27]

That said, many of the more affordable options from Hers involve compounded GLP-1s, which arent FDA-approved