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The results of this study are consistent with effects observed in clinical trials in obese patients, said Penny Ward, an independent pharmaceutical physician and visiting professor in pharmaceutical medicine at King's College London in the U.K

Cell culture systems do not replicate the complexity of whole-organism biology

PYY regulates food intake and satiety through activation of central G protein-coupled Y2 receptors on neuropeptide Y (NPY) and AgRP neurons in the hypothalamic arcuate nucleus ( 1-36 and the DPP-4-cleaved PYY 3-36 , with the latter being the most dominant postprandial circulating form ( The ability of gut microbiota to influence PYY secretion therefore has significant implications for the development of obesity and metabolic disease

Copper-doped carbon dots (Cu-CDs) exploit this weakness by selectively targeting metallothionein-2 (MT-2), a key antioxidant protein

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