Lead- and drug-like compounds: the rule-of-five revolution
For example, in a randomized double-blinded trial, NAC (600mg twice per day) given with L-arginine (1200mg per day) to diabetic men with hypertension lowered blood pressure, and improved many markers of endothelial function and inflammation, including C-reactive protein, fibrinogen, and LDL-cholesterol
as standard treatment regimens for acute MI patients have changed substantially since then (e.g., revascularization with dual antiplatelet therapy, HMG CoA reductase inhibitors), the potential benefits of L-carnitine will need to be reassessed in the context of current treatment regimens that may affect the pharmacokinetics of L-carnitine
Less common reactions include contact dermatitis (a rash or itching that doesnt resolve), persistent redness, or a localized copper reaction
WADA-prohibited Listed by the World Anti-Doping Agency under S0 (Non-Approved Substances) and prohibited at all times in sport (ref