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Dosage: More is not always better

Treatment should always be provided by a qualified healthcare professional, with dosage and frequency tailored to individual needs

For example, linear ubiquitination of HIF1 at Lys362 by LUBAC impairs its interaction with HSC70 and LAMP2A, thereby blocking CMA-mediated degradation [60]

Chauvin, J., Judee, F., Yousfi, M., Vicendo, P