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Water Retention Is Masking Progress Temporary changes in water balance can hide fat loss on the scale

How Much Weight Did Participants Lose

Figure 2 The TyG index of insulin resistance improved significantly in both cohorts of no/low CKD risk and CKD patients, and in all subgroups of the latter ( Supplementary Table 3 )

This is modest compared to 15% body weight reduction (30+ pounds for many patients) seen with injectable semaglutide 2.4 mg weekly in obesity trials