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Leukemia cells resistant to glutamine deprivation express glutamine synthetase protein
Some even experience a welcome increase in energy levels sooner than that
Human clinical trial data is extremely limited
Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]
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