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P = 0.002), from 2950 mL (95% CI: 2435, 3465) on placebo to 2460 mL (95% CI: 1946, 2475) on dulaglutide (model estimates), corresponding to a relative reduction of 17%

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The retatrutide design counters this with the simultaneous GLP-1 component, whose insulinotropic and glucose-suppressive actions offset the glucagon-driven hepatic output