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(2010): Ernhrungsmedizin
Zepbound carries a boxed warning regarding the risk of thyroid C-cell tumors observed in rodent studies, and it is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
The review warns that since VEGF/VEGFR2 pathways are active in roughly half of human cancers (from ovarian to melanoma)
At the same time, rapid weight reduction shifts the cholesterol-to-bile-salt ratio in bile toward supersaturation, creating ideal conditions for crystal nucleation and stone formation
Maintained previous BMI reduction (documentation required) OR 2
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