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This insulin resistance further promotes lipolysis in adipose tissue, releasing excessive FFAs that subsequently induce OS ( In contrast to LEP, the expression of APN is inversely related to the degree of obesity, and usually there is a decreased expression of APN in obese patients ( Figure 2b
For example, glucagon-like peptide-1 receptor agonists (GLP-1 RAs s), originally developed for the treatment of type 2 diabetes and obesity, have recently emerged as potential candidates in the treatment of SUDs (12)
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In addition to these indications, semaglutide can also support the management of various health conditions, including cardiovascular disease, depression, alcohol use, and smoking, all of which are also considered modifiable risk factors for AD
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