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In the central nervous system, these medications act on hypothalamic appetite centers to increase satiety and reduce food-seeking behavior

Notably, limited data were available for people with BMI 40 kg m 2 , the elderly, adolescents and people with overweight (BMI 25 kg m 2 and 25 kg m 2 ), with a treatment duration of at least 48 weeks, which compared OMMs with the specific indication of obesity treatment with either placebo or other OMM

Because they signal through distinct routes, they can be combined so that the body's own gland does the producing

Studies using MRI-based measurements (MRI-PDFF) have shown that semaglutide can substantially reduce hepatic fat content, with reductions correlating with the degree of weight loss achieved

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