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This study was designed to test whether AOD9604 could damage DNA or cause genetic mutationsimportant safety questions for any compound being considered for human use

The key finding was that plasma concentrations in patients taking 8 mg of retatrutide (approximately 182 nanomolar) exceeded the effective concentrations observed in the laboratory, suggesting these cardiac effects are clinically relevant at therapeutic doses

10.25011/cim.v37i3.21379 104 XuC.SunL.RenF.HuangP.TianZ.CuiJ.et al (2020)

The right dose is the lowest effective dose that achieves your goal with minimal side effects