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Tirzepatide works by mimicking two metabolic hormones in the body: it acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and also as a glucose dependent insulinotropic polypeptide (GIP) receptor agonist
The number of patients included in the studies ranges from 1 (case report) to 440.089, with a median of 355 (IQR 1295) subjects
The efficacy of low-protein diet, branched-chain amino acids (BCAA), and lactulose are the main modern treatment approaches but are insufficient in most cases
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