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Providing anti-inflammatory effects Data showed that NNMT increases collagens and inflammatory molecules, which worsen inflammation

When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

It will depend on the individuals needs

By blocking NNMT, 5-Amino-1MQ prevents NAD+ breakdown , allowing its levels to rise

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap