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Consequently, single-modality biomarkers frequently fail to generalize because they are sensitive to context (cycle phase, progesterone exposure timing, stimulation protocols, and tissue/cell-type composition), so an apparent signal in one layer may reflect unmeasured confounding rather than functional competence [447]
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A leaky gut is a known factor in the development of autoimmunity, including but not limited to thyroiditis, rheumatoid arthritis, multiple sclerosis (MS), celiac disease, and lupus
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