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Both changes sit in the region that IGF binding proteins recognise, so the analogue binds IGFBPs far more weakly than IGF-I while retaining high affinity at the type 1 IGF receptor

This is the most reproducible early signal users describe and is consistent with IGF-1's insulin-like activity

But right now it's a lot of, "Okay, well this is a lot of anecdotal evidence." And there's

If you're dealing with chronic issues, you might need weekly treatments initially, then switch to monthly maintenance sessions