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Clinical evidence for topical application includes studies using 50-100 mg/mL solutions with 5-aminolevulinic acid applied daily for 6 months
This timing accounts for the capsule passing through the stomach and bicarbonate being absorbed into the bloodstream
The publication of high-quality mechanistic studies, coupled with small human trials showing functional endocrine and immune effects , has elevated the peptide from fringe curiosity to a serious candidate in the longevity toolkit
doi: 10.1016/j.xfss.2020.12.001 135 CuiPShiJMMaTRaoLTongXYHuWet al
Khozin-Goldberg, Z
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