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This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism

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CYP1A homologues also metabolize AFB 1 to produce the detoxified metabolite AFM 1 , whereas CYP3A enzymes - P450 III AY and in the fetal liver P450 III A6 , produce another detoxified metabolite, aflatoxin Q 1 (AFQ 1 ), the major metabolite of AFB 1 (Figure 2)